METHOD FOR PREDICTING THE DEVELOPMENT OF A HIGH DEGREE OF SEVERITY OF THE INFLAMMATORY PROCESS IN CHILDREN WITH ACUTE PNEUMONIA
| Autor: | Parfionova I. V., Maksimovich N. A. |
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| Jazyk: | Belarusian<br />English<br />Russian |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, Vol 18, Iss 4, Pp 452-456 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2221-8785 2413-0109 |
| DOI: | 10.25298/2221-8785-2020-18-4-452-456 |
| Popis: | Aim of study. To identify a set of independent factors and develop a method for predicting the high degree of severity of the inflammatory process in children with acute community-acquired pneumonia. Material and methods. A cohort of 100 patients was examined, including children with acute pneumonia with (n=70) and without (n=30) endothelial dysfunction. All children underwent a comprehensive study, which included a clinical examination, laboratory studies according to generally accepted methods. The study of the function of external respiration was carried out using the spirograph “Spiro-spectrum”. Determination of the content of nitric oxide in blood serum was performed by spectrophotometric method using cadmium and Griss reagent, circulating endothelial cells by microscopy. Results. A regression model was created that enables to predict the probability of a high degree of inflammatory process in children with segmental and lobar pneumonia (sensitivity 96.4%, specificity 93.3%). Conclusions. The use of the regression equation enabled to develop a method for predicting the probability of a high degree of inflammatory process in children with segmental and lobar pneumonia that have signs of endothelial dysfunction, and as a result – to choose the optimal management strategy for such patients. |
| Databáze: | Directory of Open Access Journals |
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