| Autor: |
Xiu-qing Lin, Wei Wu, Xin Chen, Ren-pin Chen, Fang Wu, Zhou-feng Chen, Er-jiong Huang, Chao Chen |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Frontiers in Bioscience-Landmark, Vol 25, Iss 3, Pp 452-462 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2768-6701 |
| DOI: |
10.2741/4813 |
| Popis: |
Gastric cancer is the fourth most common malignancy world-wide that bears a high mortality by invasiveness and metastases. To this end, we examined the role of miR-1 in mobility and migration of gastric cancer cells. miR-1 was down-regulated and Sorcin, which supports invasion, was highly expressed in gastric cancer cell lines as compared to the control. The overexpression of miR-1 significantly inhibited the mobility and migration of gastric cancer cells, while, its knockdown exerted an oppoiste effect. In addition, while overexpression of miR-1 suppressed the expression of Sorcin, the siRNA knockdown of Sorcin significantly counteracted the effect of miR-1 inhibitor on cell invasion and migration of gastric cancer cells. A miR-1 mimic decreased while its inhibitor increased the MMP-7 and VEGF required for invasion. Taken together, the findings support the view that miR-1 controls the mobility and migration of gastric cancer cells and might be a therapeutic target for blocking gastric cancer invasion. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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