| Autor: |
Bin Song, Rurun Li, Zhihua Zuo, Juan Tan, Ling Liu, Dafa Ding, Yibing Lu, Dawei Hou |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2407 |
| DOI: |
10.1186/s12885-019-5533-4 |
| Popis: |
Abstract Background Papillary thyroid cancer (PTC) is the most frequent type of thyroid malignancy. In this study, we investigated the mechanisms whereby long non-coding RNAs (lncRNAs) are associated with PTC pathogenesis. Methods Microarray analysis was used to determine differentially expressed lncRNAs between paired PTC tissues and normal adjacent thyroid tissues. Quantitative RT-PCR was used for validation in 86 PTC cases. Small interfering RNA (siRNA) transfection assays were then performed to assess how a novel lncRNA affected key proliferation and cell death pathways in IHH4 PTC cells. Results We identified 1878 differentially expressed lncRNAs versus matched control samples (fold change ≥2.0, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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