Connecting multiple microenvironment proteomes uncovers the biology in head and neck cancer

Autor: Ariane F. Busso-Lopes, Leandro X. Neves, Guilherme A. Câmara, Daniela C. Granato, Marco Antônio M. Pretti, Henry Heberle, Fábio M. S. Patroni, Jamile Sá, Sami Yokoo, César Rivera, Romênia R. Domingues, Ana Gabriela C. Normando, Tatiane De Rossi, Barbara P. Mello, Nayane A. L. Galdino, Bianca A. Pauletti, Pammela A. Lacerda, André Afonso N. Rodrigues, André Luis M. Casarim, Reydson A. de Lima-Souza, Ingrid I. Damas, Fernanda V. Mariano, Kenneth J. Gollob, Tiago S. Medina, Nilva K. Cervigne, Ana Carolina Prado-Ribeiro, Thaís Bianca Brandão, Luisa L. Villa, Miyuki Uno, Mariana Boroni, Luiz Paulo Kowalski, Wilfredo Alejandro González-Arriagada, Adriana F. Paes Leme
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-24 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-34407-1
Popis: The biological understanding of poor prognosis associated with lymph node metastasis in head and neck cancer (HNC) remains crucial. Here, a proteomic characterisation of 140 multisite samples from a 59-HNC patient cohort and machine learning reveals potential biomarkers and metastasis related signatures.
Databáze: Directory of Open Access Journals