Rebound-associated vertebral fractures after denosumab discontinuation in a lung cancer patient with bone metastases

Autor: Jolan Dupont, Wesley Appermans, Marian Dejaeger, Isabelle Wauters, Michaël R. Laurent, Evelien Gielen
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Bone Reports, Vol 16, Iss , Pp 101582- (2022)
Druh dokumentu: article
ISSN: 2352-1872
DOI: 10.1016/j.bonr.2022.101582
Popis: Denosumab is a commonly used antiresorptive treatment in patients with osteoporosis or solid tumours with bone metastases. Upon denosumab discontinuation, a rebound phenomenon can occur that results in an increased (vertebral) fracture risk. This phenomenon is well-known in the setting of osteoporosis but rarely reported in cancer patients with bone metastases discontinuing denosumab. We present the case of a 43-year old women with lung cancer and bone metastases who suffered multiple vertebral fractures after discontinuation of denosumab.
Databáze: Directory of Open Access Journals