Clinical Implications of Physical Function and Resilience in Patients Undergoing Transcatheter Aortic Valve Replacement

Autor: Kashish Goel, Jared M. O’Leary, Colin M. Barker, Melissa Levack, Vivek Rajagopal, Raj R. Makkar, Tanvir Bajwa, Neal Kleiman, Axel Linke, Dean J. Kereiakes, Ron Waksman, Dominic J. Allocco, David G. Rizik, Michael J. Reardon, Brian R. Lindman
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 17 (2020)
Druh dokumentu: article
ISSN: 2047-9980
DOI: 10.1161/JAHA.120.017075
Popis: Background Gait speed is a reliable measure of physical function and frailty in patients with aortic stenosis undergoing transcatheter aortic valve replacement (TAVR). Slow gait speed pre‐TAVR predicts worse clinical outcomes post‐TAVR. The consequences of improved versus worsened physical function post‐TAVR are unknown. Methods and Results The REPRISE III (Repositionable Percutaneous Replacement of Stenotic Aortic Valve Through Implantation of Lotus Valve System–Randomized Clinical Evaluation) trial randomized high/extreme risk patients to receive a mechanically‐expanded or self‐expanding transcatheter heart valve. Of 874 patients who underwent TAVR, 576 with complete data at baseline and 1 year were included in this analysis. Slow gait speed in the 5‐m walk test was defined as
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