Maternal Gut Microbiota in Pregnancies Resulting in Down Syndrome Newborns – a Pilot Study
| Autor: | Mehmet Hursitoglu, Alev Kural, Sibel Kuras, Esra Akdeniz, Salim Sezer, Sema Suzen Caypinar, Cemal Kazezoglu, Bulent Yaprak, Faruk Karandere, Hamit Zafer Guven |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Acta Clinica Croatica, Vol 60., Iss 4., Pp 722-730 (2021) |
| Druh dokumentu: | article |
| ISSN: | 0353-9466 1333-9451 19141033 |
| DOI: | 10.20471/acc.2021.60.04.20 |
| Popis: | Down syndrome (DS) is one of the main genetic abnormalities of newborns. Therefore, prenatal diagnosis of this syndrome is of paramount importance to the family and the community. The microbiota system is important in early brain development. We tried to study and compare gut microbiota (GM) composition in pregnancies that resulted in DS neonates with pregnancies that resulted in healthy children. The study population consisted of 21 pregnant women having delivered DS newborns (group 1) and 22 pregnant women who had given birth to healthy newborns (group 2). The GM composition was determined and compared between the two groups. There were no significant age and gestational age differences between the two groups (p>0.005 both). Regarding GM analysis, microorganisms of the families Clostridiaceae and Pasteurellaceae were more abundant in the group of women having delivered DS neonates than the group of women having delivered healthy newborns (p |
| Databáze: | Directory of Open Access Journals |
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