High-Throughput Screen for Inhibitors of the Type IV Pilus Assembly ATPase PilB

Autor: Keane J. Dye, Nancy J. Vogelaar, Pablo Sobrado, Zhaomin Yang
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: mSphere, Vol 6, Iss 2 (2021)
Druh dokumentu: article
ISSN: 2379-5042
DOI: 10.1128/mSphere.00129-21
Popis: Many bacterial pathogens use their type IV pili (T4P) to facilitate and maintain infection of a human host. Small chemical compounds that inhibit the production or assembly of T4P have promise in the treatment and prevention of infections, especially in the era of increasing threats from antibiotic-resistant bacteria.
Databáze: Directory of Open Access Journals