Sensory Phenotype of the Oesophageal Mucosa in Gastro-Oesophageal Reflux Disease

Autor:	Ahsen Ustaoglu, Philip Woodland
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	GORD peripheral sensitization heartburn oesophageal mucosa Biology (General) QH301-705.5 Chemistry QD1-999
Zdroj:	International Journal of Molecular Sciences, Vol 24, Iss 3, p 2502 (2023)
Druh dokumentu:	article
ISSN:	1422-0067 1661-6596 34131876
DOI:	10.3390/ijms24032502
Popis:	Gastroesophageal reflux disease (GORD) affects up to 20% of Western populations, yet sensory mechanisms underlying heartburn pathogenesis remain incompletely understood. While central mechanisms of heartburn perception have been established in earlier studies, recent studies have highlighted an important role of neurochemical, inflammatory, and cellular changes occurring in the oesophageal mucosa itself. The localization and neurochemical characterisation of sensory afferent nerve endings differ among GORD phenotypes, and could explain symptom heterogeneity among patients who are exposed to similar levels of reflux. Acid-induced stimulation of nociceptors on pain-sensing nerve endings can regulate afferent signal transmission. This review considers the role of peripheral mechanisms of sensitization in the amplification of oesophageal sensitivity in patients with GORD.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/4ca3413187624bbca4d9ba3fac6be319 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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