| Autor: |
Elizabeth Alwers, Jakob N Kather, Matthias Kloor, Alexander Brobeil, Katrin E Tagscherer, Wilfried Roth, Amelie Echle, Efrat L Amitay, Jenny Chang‐Claude, Hermann Brenner, Michael Hoffmeister |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
The Journal of Pathology: Clinical Research, Vol 9, Iss 2, Pp 129-136 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2056-4538 |
| DOI: |
10.1002/cjp2.304 |
| Popis: |
Abstract In addition to the traditional staging system in colorectal cancer (CRC), the Immunoscore® has been proposed to characterize the level of immune infiltration in tumor tissue and as a potential prognostic marker. The aim of this study was to examine and validate associations of an immune cell score analogous to the Immunoscore® with established molecular tumor markers and with CRC patient survival in a routine setting. Patients from a population‐based cohort study with available CRC tumor tissue blocks were included in this analysis. CD3+ and CD8+ tumor infiltrating lymphocytes in the tumor center and invasive margin were determined in stained tumor tissue slides. Based on the T‐cell density in each region, an immune cell score closely analogous to the concept of the Immunoscore® was calculated and tumors categorized into IS‐low, IS‐intermediate, or IS‐high. Logistic regression models were used to assess associations between clinicopathological characteristics with the immune cell score, and Cox proportional hazards models to analyze associations with cancer‐specific, relapse‐free, and overall survival. From 1,535 patients with CRC, 411 (27%) had IS‐high tumors. Microsatellite instability (MSI‐high) was strongly associated with higher immune cell score levels (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Plný text