Age and Racial Differences Among PSA-Detected (AJCC Stage T1cN0M0) Prostate Cancer in the U.S.: A Population-Based Study of 70,345 Men

Autor: Hong eZhang, Edward M Messing, Lois B Travis, Ollivier eHyrien, Rui eChen, Michael T Milano, Yuhchyau eChen
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Frontiers in Oncology, Vol 3 (2013)
Druh dokumentu: article
ISSN: 2234-943X
DOI: 10.3389/fonc.2013.00312
Popis: Purpose: Few studies have evaluated the risk profile of PSA-detected T1cN0M0 prostate cancer, defined as tumors diagnosed by needle biopsy because of elevated PSA levels without other clinical signs of disease. However, some men with stage T1cN0M0 prostate cancer may have high-risk disease, thus experiencing inferior outcomes as predicted by a risk group stratification model.Methods: We identified men diagnosed with stage T1cN0M0 prostate cancer from 2004-2008 reported to the SEER program. Multivariate logistic regression was used to model the probability of intermediate-risk (PSA >10 ng/ml but < 20 ng/ml and/or GS 7), and high-risk disease (PSA >20 ng/ml, and/or GS ≥8), relative to low-risk disease (PSA
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