Diagnostic value of preoperative systemic inflammatory markers in patients with intracranial meningiomas
| Autor: | Rahsan Kemerdere, Mehmet Yigit Akgun, Sureyya Toklu, Orkhan Alizada, Oguz Baran, Taner Tanriverdi |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Romanian Neurosurgery, Vol 32, Iss 4 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1220-8841 2344-4959 |
| Popis: | Introduction: The role of inflammation in cancer has been defined, and now, inflammation is accepted as one of the hallmarks of cancer development. The aim of this study was to evaluate the difference regarding preoperative neutrophil to lymphocyte (NLR) and platelet to lymphocyte ratios (PLR) in patients with meningioma between patients and healthy controls and between grade-I and grade-II meningiomas. Methods: Retrospective analysis of preoperative neutrophil, lymphocyte, monocyte, and platelet counts and NLR, and PLR were evaluated in 61 patients underwent meningioma surgery. Results: Neutrophil count was significantly increased while lymphocyte count significantly decreased patients compared to controls. Similar findings were obtained in grade-II meningiomas compared with grade-I meningiomas. NLR were significantly higher in both grade-I and grade-II meningiomas than controls. Conclusion: We for the first time provided that higher NLR may be associated with grading of meningioma and be a predictive factor for progression of meningiomas. The use of medication against neutrophil-related inflammation may be helpful for patients with higher grade of meningioma decreasing peritumoral edema before and after surgery. |
| Databáze: | Directory of Open Access Journals |
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