Propranolol significantly reduced DNA polymerase β expression in patients with essential tremor
| Autor: | Nefise Kandemir, Sercan Kenanoglu, Murat Gultekin, Nuriye Gokce, Hilal Akalin, Nazife Taşçıoğlu, Meral Mirza, Emel Koseoglu, Munis Dundar |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Universa Medicina, Vol 40, Iss 3 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1907-3062 2407-2230 |
| DOI: | 10.18051/UnivMed.2021.v40.207-215 |
| Popis: | Background Essential tremor (ET) is the most common movement disorder. Propranolol is a first-line medication for ET. We aimed to evaluate the effect of propranolol on the expression of poly (ADP-ribose) polymerase 1 (PARP1) and DNA polymerase beta (POLB) genes, which are known to be related to neurodegenerative diseases, in patients with ET. Methods Thirty-five healthy volunteers and thirty-five patients followed up with essential tremors were included in a non-randomized control experimental study. Expressions of PARP1 and POLB genes were compared between the control group and the patient group. In addition, pre- and post-treatment gene expression levels and Fahn-Tolosa-Marin tremor scale values of the patient group were compared after 8 weeks of propranolol treatment. The Wilcoxon rank and Mann Whitney U tests were used to analyze the data. Results At baseline, PARP1 expression was significantly lower in the ET group than in the control group. (p |
| Databáze: | Directory of Open Access Journals |
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