From Lipid Homeostasis to Differentiation: Old and New Functions of the Zinc Cluster Proteins Ecm22, Upc2, Sut1 and Sut2

Autor:	Ifeoluwapo Matthew Joshua, Thomas Höfken
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	zinc cluster protein transcription factor sterol uptake sterol biosynthesis anaerobic filamentation mating budding yeast Candida antifungal Biology (General) QH301-705.5 Chemistry QD1-999
Zdroj:	International Journal of Molecular Sciences, Vol 18, Iss 4, p 772 (2017)
Druh dokumentu:	article
ISSN:	1422-0067 18040772
DOI:	10.3390/ijms18040772
Popis:	Zinc cluster proteins are a large family of transcriptional regulators with a wide range of biological functions. The zinc cluster proteins Ecm22, Upc2, Sut1 and Sut2 have initially been identified as regulators of sterol import in the budding yeast Saccharomyces cerevisiae. These proteins also control adaptations to anaerobic growth, sterol biosynthesis as well as filamentation and mating. Orthologs of these zinc cluster proteins have been identified in several species of Candida. Upc2 plays a critical role in antifungal resistance in these important human fungal pathogens. Upc2 is therefore an interesting potential target for novel antifungals. In this review we discuss the functions, mode of actions and regulation of Ecm22, Upc2, Sut1 and Sut2 in budding yeast and Candida.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/4c786861922f49858aabc1030c9edca4 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF