Renal nerve stimulation identifies renal innervation and optimizes the strategy for renal denervation in canine

Autor: Hang Liu, Yidan Li, Hao Zhou, Weijie Chen, Yanping Xu, Huaan Du, Bo Zhang, Tianli Xia, Dan Li, Zhenhong Ou, Ruotian Tang, Qingsong Chen, Binyi Zhao, Yuehui Yin
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-13 (2023)
Druh dokumentu: article
ISSN: 1479-5876
DOI: 10.1186/s12967-023-03919-9
Popis: Abstract Background Renal denervation (RDN) was still performed without any intra-procedural method for nerve mapping. Whether renal nerve stimulation (RNS) is an efficient way to identify renal autonomic innervation and optimize the strategy for RDN remain to be worthy for further exploration. Methods The characteristics of renal autonomic innervation at the sites with different blood pressure (BP) responses to RNS were explored. Then, dogs anatomically eligible for RDN were randomly assigned into elevated BP response ablation group, reduced BP response ablation group, and RNS-control group. The postoperative outcomes were measured at baseline and after 4 weeks follow-up. Results The proportion of afferent sensory nerve was higher at elevated BP response sites (ERS) than reduced BP response sites (RRS) and non-response sites (NRS) (P = 0.012 and P = 0.004). Conversely, the proportion of parasympathetic nerve at RRS was the highest (RRS vs. ERS, P = 0.017; RRS vs. NRS, P = 0.023). More importantly, there was a significant correlation between systolic blood pressure changes and the area ratios of afferent sensory and parasympathetic nerve (R = 0.859; P
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