Photodynamic Inactivation of Microorganisms Using Semisynthetic Chlorophyll a Derivatives as Photosensitizers

Autor:	Marciana Pierina Uliana, Andréia da Cruz Rodrigues, Bruno Andrade Ono, Sebastião Pratavieira, Kleber Thiago de Oliveira, Cristina Kurachi
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Spirulina maxima chlorophyll a derivatives photosensitizers semisynthesis photodynamic inactivation Organic chemistry QD241-441
Zdroj:	Molecules, Vol 27, Iss 18, p 5769 (2022)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules27185769
Popis:	In this study, we describe the semisynthesis of cost-effective photosensitizers (PSs) derived from chlorophyll a containing different substituents and using previously described methods from the literature. We compared their structures when used in photodynamic inactivation (PDI) against Staphylococcus aureus, Escherichia coli, and Candida albicans under different conditions. The PSs containing carboxylic acids and butyl groups were highly effective against S. aureus and C. albicans following our PDI protocol. Overall, our results indicate that these nature-inspired PSs are a promising alternative to selectively inactivate microorganisms using PDI.
Databáze:	Directory of Open Access Journals
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