Hemostatic efficacy of two topical adjunctive hemostats in a porcine spleen biopsy punch model of moderate bleeding

Autor: Melinda H. MacDonald, Gary Zhang, Laura Tasse, Daidong Wang, Hector De Leon, Richard Kocharian
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Materials Science: Materials in Medicine, Vol 32, Iss 10, Pp 1-13 (2021)
Druh dokumentu: article
ISSN: 0957-4530
1573-4838
DOI: 10.1007/s10856-021-06586-8
Popis: Abstract Topical hemostatic agents have become essential tools to aid in preventing excessive bleeding in surgical or emergency settings and to mitigate the associated risks of serious complications. In the present study, we compared the hemostatic efficacy of SURGIFLO® Hemostatic Matrix Kit with Thrombin (Surgiflo—flowable gelatin matrix plus human thrombin) to HEMOBLAST™ Bellows Hemostatic Agent (Hemoblast—a combination product consisting of collagen, chondroitin sulfate, and human thrombin). Surgiflo and Hemoblast were randomly tested in experimentally induced bleeding lesions on the spleens of four pigs. Primary endpoints included hemostatic efficacy measured by absolute time to hemostasis (TTH) within 5 min. Secondary endpoints included the number of product applications and the percent of product needed from each device to achieve hemostasis. Surgiflo demonstrated significantly higher hemostatic efficacy and lower TTH (p
Databáze: Directory of Open Access Journals
Externí odkaz: