Curcumin Loaded PEGylated Nanoemulsions Designed for Maintained Antioxidant Effects and Improved Bioavailability: A Pilot Study on Rats

Autor:	Jelena B. Đoković, Sanela M. Savić, Jelena R. Mitrović, Ines Nikolic, Bojan D. Marković, Danijela V. Randjelović, Jelena Antic-Stankovic, Dragana Božić, Nebojša D. Cekić, Vladimir Stevanović, Bojan Batinić, Jovana Aranđelović, Miroslav M. Savić, Snežana D. Savić
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	curcumin PEGylated nanoemulsions long-term stability experimental design Biology (General) QH301-705.5 Chemistry QD1-999
Zdroj:	International Journal of Molecular Sciences, Vol 22, Iss 15, p 7991 (2021)
Druh dokumentu:	article
ISSN:	1422-0067 1661-6596
DOI:	10.3390/ijms22157991
Popis:	The current study describes the experimental design guided development of PEGylated nanoemulsions as parenteral delivery systems for curcumin, a powerful antioxidant, as well as the evaluation of their physicochemical characteristics and antioxidant activity during the two years of storage. Experimental design setup helped development of nanoemulsion templates with critical quality attributes in line with parenteral application route. Curcumin-loaded nanoemulsions showed mean droplet size about 105 nm, polydispersity index
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/e4c6734099564c2a86913584c7b604fa Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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