Risk Factors Associated with Pyogenic Spinal Infections among Intravenous Drug Users and Nonusers

Autor: Vivek K. Bilolikar, Brendan Gleason, Lee Kripke, Robert Merrill, Colin Whitaker, Jon Handal
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Advances in Orthopedics, Vol 2024 (2024)
Druh dokumentu: article
ISSN: 2090-3472
DOI: 10.1155/2024/9938159
Popis: Background Data. Spinal infections are major clinical problems with a substantial financial burden on healthcare systems. Recent increases in primary pyogenic spine infections can be attributed to the opioid epidemic and an aging and increasingly unhealthy population. Immunocompromise, diabetes, and malignancy all predispose patients to spine infections. Purpose. To identify the differences in patient factors, presentation, treatment course, and outcomes of intravenous drug users (IVDA) vs. nonusers (non-IVDA) presenting with pyogenic spinal infections. Study Design/Setting. Retrospective case series. Methods. We identified all cases involving spinal infections at our institution between May 2017 and January 2023. Postsurgical infections were excluded, and patients were separated into IVDA and non-IVDA groups. The patient charts were reviewed and analyzed for statistical or clinically significant differences using RStudio (2019 version 3.6.2). Our institutional review board approved this study, IRB# 2020-277, iRISID-2023-1384. Results. Fifty patients (29 males and 21 females) with primary pyogenic spinal infections were included in our study. There were fourteen patients (28.0%) in the IVDA group. The mean age in the IVDA group was 50.6 vs. 61.9 years (p
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