Five-Year Risk of Basal Cell Carcinoma Recurrence After a Conventional Surgical Excision
| Autor: | Bruno Duarte, Luis Vieira, Luis Ribeiro, Tomás Pessoa e Costa, Alexandre João, Alice Varanda, Joana Cabete |
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| Jazyk: | English<br />Portuguese |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Revista da Sociedade Portuguesa de Dermatologia e Venereologia, Vol 78, Iss 2 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2182-2395 2182-2409 |
| DOI: | 10.29021/spdv.78.2.1174 |
| Popis: | Introduction: Basal cell carcinomas are mostly treated surgically, mostly by surgery with postoperative histopathologic margin evaluation (“conventional surgery”), but large long-term data regarding recurrence by completeness of excisions is limited. Methods: Retrospective cohort study of basal cell carcinomas treated by conventional surgery at different medical specialties in a large tertiary centre, between 2008 and 2014. Survival analysis with a Cox proportional-hazards was performed, stratified by completeness of excision (complete excision/incomplete excision) and adjusted to several potentially confounding covariates. Results: A total of 2876 basal cell carcinomas were identified, of which 2306 (2100 primary, 206 recurrent) were considered eligible for analysis. During the 5-years of follow-up, there were 80 (4%) recurrences among 1980 complete excisions (16/1000 cases-year) and 83 (23.9%) recurrences among 348 incomplete excisions (100/1000 cases-year). Survival analysis was performed with multivariable adjustment. In the final adjusted model, we identified an association between relapse and re-intervention on recurrent tumors [adjusted Hazard Ratio (HR) 2.20 (95% Confidence interval (IC), 1.26-3.84), p=0.006], a wrong preoperative clinical diagnosis/surgery devoid of preoperative biopsy [adjusted HR 2.75 (95% CI, 1.68-4.5), p |
| Databáze: | Directory of Open Access Journals |
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