| Autor: |
Eray Hasırcı, Enis Kervancıoğlu, Cevahir Özer, S. Remzi Erdem, Mehmet Reşit Gören |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Journal of Urological Surgery, Vol 11, Iss 2, Pp 99-104 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2148-9580 |
| DOI: |
10.4274/jus.galenos.2023.2023-7-8 |
| Popis: |
Objective: We aimed to investigate the role of apoptosis and its effects on cavernosal smoothmuscle (CSM) function after ischemic priapism (IP) in a rat model. Materials and Methods: Twelve adult Sprague-Dawley rats were assigned into two groups: The priapism and control groups. In all rats, erections were obtained by the vacuum method; however, in the priapism group, erections were maintained with a rubber band for 4 h to mimic priapism. After 14 days following this procedure, penile excision was performed and cavernosal tissues were investigated pharmacologically and histopathologically. Isometric tension changes due to several contractile and relaxant pharmacological agents were investigated with/without nitric oxide synthase (NOS) and guanylate cyclase (GC) inhibition. Results: Isometric contraction and relaxation responses due to the agents applied did not differ between the groups. However, with NOS and GC inhibition, the cavernosal tissues relaxed less in the priapism group than in the controls (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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