Desenvolvimento e validação de método para o doseamento de tibolona em cápsulas por cromatografia líquida de alta eficiência
| Autor: | Hernandez Bozardi da Rosa, Renata Cristine Tolotti, Diogo dos Santos Miron, Kellen Cristhinia Borges de Souza |
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| Jazyk: | English<br />Spanish; Castilian<br />Portuguese |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Química Nova, Vol 35, Iss 5, Pp 1030-1035 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1678-7064 0100-4042 |
| DOI: | 10.1590/S0100-40422012000500030 |
| Popis: | Tibolone is a synthetic steroid used for prevention of bone loss and treatment of menopause symptoms. This article describes the development and validation of an analytical method to quantify tibolone in capsules using high performance liquid chromatography with UV detection. After chromatography conditions are established the validation parameters evaluated were specificity, linearity, precision, accuracy, detection and quantification limits and robustness. The method developed is effective to analyze tibolone in capsules, being able to be used in quality control laboratory routine. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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