Multipronged strategy for protection and motivation of healthcare workers during the COVID-19 pandemic: a real-life study

Autor: Madhumita Premkumar, Usha Dutta, Anchal Sandhu, Harman Kaur, Mini P Singh, Kapil Goyal, Rashmi Ranjan Guru, PVM Lakshmi, Madhu Gupta, Manisha Biswal, Arnab Ghosh, Anurag Sachan, Shikha Guleria, Swapanjeet Sahoo, Sandeep Grover, Tulika Gupta, Vipin Koushal, Mahesh Devnani, Shweta Talati, Ritin Mohindra, Vikas Suri, RK Ratho, Ashish Bhalla, Sanjay Jain, Pankaj Arora, Navin Pandey, Ashok Kumar, Arun K. Aggarwal, Arunaloke Chakrabarti, Goverdhan Dutt Puri, Jagat Ram, SS Pandav, Rakesh Sehgal, Pankaj Malhotra, Narayana Yaddanapuddi, Surjeet Singh, PGIMER COVID-19 Healthcare Worker Welfare Taskforce
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Antimicrobial Stewardship & Healthcare Epidemiology, Vol 4 (2024)
Druh dokumentu: article
ISSN: 2732-494X
34085947
DOI: 10.1017/ash.2023.459
Popis: Abstract Objective: We aimed to assess risk of COVID-19 infection & seroprotection status in healthcare workers (HCWs) in both hospital and community settings following an intensive vaccination drive in India. Setting: Tertiary Care Hospital Methods: We surveyed COVID-19 exposure risk, personal protective equipment (PPE) compliance, vaccination status, mental health & COVID-19 infection rate across different HCW cadres. Elecsys® test for COVID-19 spike (Anti-SARS-CoV-2S; ACOVs) and nucleocapsid (Anti-SARS-CoV-2; ACOV) responses following vaccination and/or COVID-19 infection were measured in a stratified sample of 386 HCW. Results: We enrolled 945 HCWs (60.6% male, age 35.9 ± 9.8 years, 352 nurses, 211 doctors, 248 paramedics & 134 support staff). Hospital PPE compliance was 90.8%. Vaccination coverage was 891/945 (94.3%). ACOVs neutralizing antibody was reactive in 381/386 (98.7%). ACOVs titer (U/ml) was higher in the post-COVID-19 infection group (N =269; 242.1 ± 35.7 U/ml) than in the post-vaccine or never infected subgroup (N = 115, 204.1 ± 81.3 U/ml). RT PCR + COVID-19 infections were documented in 224/945 (23.7%) and 6 HCWs had disease of moderate severity, with no deaths. However, 232/386 (60.1%) of HCWs tested positive for nucleocapsid ACOV antibody, suggesting undocumented or subclinical COVID-19 infection. On multivariate logistic regression, only female gender [aOR 1.79, 95% CI 1.07–3.0, P = .025] and COVID-19 family contact [aOR 5.1, 95% CI 3.84–9.5, P < .001] were predictors of risk of developing COVID-19 infection, independent of association with patient-related exposure. Conclusion: Our HCWs were PPE compliant and vaccine motivated, with immunization coverage of 94.3% and seroprotection rate of 98.7%. There was no relationship between HCW COVID-19 infection to exposure characteristics in the hospital. Vaccination reduced disease severity and prevented death in HCW.
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