Interleukin 17A and Toll-like Receptor 4 in Patients with Arterial Hypertension

Autor:	Tihana Simundic, Bojan Jelakovic, Andrea Dzumhur, Tajana Turk, Ines Sahinovic, Blazenka Dobrosevic, Boris Takac, Jerko Barbic
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	Arterial hypertension Toll-like receptor 4 Interleukin 17A Innate immunity Adaptive immunity Dermatology RL1-803 Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the genitourinary system. Urology RC870-923
Zdroj:	Kidney & Blood Pressure Research, Vol 42, Iss 1, Pp 99-108 (2017)
Druh dokumentu:	article
ISSN:	1420-4096 1423-0143
DOI:	10.1159/000471900
Popis:	Background/Aims: Immune responses are involved in arterial hypertension. An observational cross-sectional case control study was conducted to estimate the association between Toll-like receptor 4 (TLR4) expression and interleukin (IL)-17A serum levels in patients with controlled and non-controlled hypertension. Methods: We have enrolled 105 non-complicated otherwise healthy hypertensive patients: 53 with well-controlled blood pressure and 52 non-controlled. TLR4 peripheral monocytes expression and serum IL-17A levels were determined by flow cytometry and ELISA, respectively. Results: Non-controlled patients exhibited higher TLR4 expression than well-controlled (25.60 vs. 21.99, P=0.011). TLR4 expression was lower in well-controlled patients who were prescribed beta blockers (18.9 vs. 22.6, P=0.005) and IL-17A concentration was higher in patients using diuretics in either group (1.41 vs. 2.01 pg/ml, P
Databáze:	Directory of Open Access Journals
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