Exploration for the opioidergic, GABAergic and histaminergic potentials of synthesized Schiff’s base derivatives: An in-vivo approach

Autor: Adnan Khan, Sajjad Khan, Zia Ullah, Syed Wadood Ali Shah, Muhammad Shoaib, Muhammad Zahoor, Riaz Ullah, Zafar Iqbal, Muhammad Naveed Umar, Essam A. Ali
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Results in Chemistry, Vol 10, Iss , Pp 101716- (2024)
Druh dokumentu: article
ISSN: 2211-7156
DOI: 10.1016/j.rechem.2024.101716
Popis: Herein, five Schiff’s base analogs (designated as AK1 to AK5) were synthesized and screened for their analgesic and anti-inflammatory efficacies. All compounds exhibited analgesic activity at selected doses from 45.31 % to 75.75 %, while the standard drug diclofenac sodium produced result as 86.33 %. Compounds AK1, AK3, AK4 and AK5 were found significantly P
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