| Autor: |
Gurman Kaur, Stephanie Gras, Jesse I. Mobbs, Julian P. Vivian, Adrian Cortes, Thomas Barber, Subita Balaram Kuttikkatte, Lise Torp Jensen, Kathrine E. Attfield, Calliope A. Dendrou, Mary Carrington, Gil McVean, Anthony W. Purcell, Jamie Rossjohn, Lars Fugger |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/ncomms15924 |
| Popis: |
HLA-C expression levels correlate with immune responses to pathogens and autoimmunity, and vary in an allele-specific manner across individuals. Here the authors identify factors that drive differential expression of HLA-C allomorphs at the cell surface, and influence the structure of the peptide-binding cleft and diversity of peptides bound by HLA-C molecules. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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