Synthesis and Investigation of Tetrahydro-β-carboline Derivatives as Inhibitors of Plant Pathogenic Fungi

Autor:	Koonchira Buaban, Weerachai Phutdhawong, Thongchai Taechowisan, Waya S. Phutdhawong
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	tetrahydro-β-carbolines (THβCs) plant pathogenic fungi radial growth N-substituted THβCs Organic chemistry QD241-441
Zdroj:	Molecules, Vol 26, Iss 1, p 207 (2021)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules26010207
Popis:	A series of tetrahydro-ß-carbolines substituted with an alkyl or acyl side chain was synthesized and screened for its antifungal activity against plant pathogenic fungi (Bipolaris oryzae, Curvularia lunata, Fusarium semitectum, and Fusarium fujikuroi). The structure activity relationship revealed that the substituent at the piperidine nitrogen plays an important role for increasing antifungal activities. In this series, 2-octyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (3g) displayed potent antifungal activities with a minimum inhibitory concentration of 0.1 μg/mL, including good inhibitory activity to the radial growth of fungus at a concentration of 100 μg/mL compared to amphotericin B.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/4c231426027c4fa4beae26ad7a85843c Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.