Effect of bile reflux on gastric juice microbiota in patients with different histology phenotypes

Autor: Yong Sung Kim, Tatsuya Unno, Seon-Young Park, Jin Ook Chung, Yoo-Duk Choi, Su-Mi Lee, Seong Hyun Cho, Dong Hyun Kim, Hyun-Soo Kim, Young Do Jung
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Gut Pathogens, Vol 16, Iss 1, Pp 1-10 (2024)
Druh dokumentu: article
ISSN: 1757-4749
DOI: 10.1186/s13099-024-00619-7
Popis: Abstract Background/aims Bile reflux (BR) can influence the gastric environment by altering gastric acidity and possibly the gastric microbiota composition. This study investigated the correlation between bile acids and microbial compositions in the gastric juice of 50 subjects with differing gastric pathologies. Methods This study included 50 subjects, which were categorized into three groups based on the endoscopic BR grading system. The primary and secondary bile acid concentrations in gastric juice samples were measured, and microbiota profiling was conducted using 16 S rRNA gene sequencing. Results Significant differences were observed in each bile acid level in the three endoscopic BR groups (P
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