Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox

Autor:	Mayuko Amagai, Sadanori Furudate, Kentaro Ohuchi, Toshiya Takahashi, Emi Yamazaki, Hiromu Chiba, Yoshihide Asano, Taku Fujimura
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	pcalcl denileukin diftitox chemotherapy tumor-infiltrating cells granulysin Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Case Reports in Oncology, Vol 15, Iss 2, Pp 726-731 (2022)
Druh dokumentu:	article
ISSN:	1662-6575
DOI:	10.1159/000526312
Popis:	Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare variant of cutaneous T cell lymphoma (CTCL) characterized by CD30-expressing large atypical cells with kidney-shaped nuclei called hallmark cells. Since PCALCL is a rare variant of CTCL, the treatment of PCALCL is still controversial. In this report, a case of PCALCL successfully treated with denileukin diftitox as second-line therapy is described. Interestingly, the administration of denileukin diftitox decreased CD8+ T cells, CD25+ cells, granulysin-bearing lymphocytes, and CD163+ macrophages. The present case suggests that denileukin diftitox might induce an anti-lymphoma effect as well as modulate the tumor microenvironment.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/4c18d05cfbc04ba99174a9bbf344291b Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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