Treatment of subclinical hyperthyroidism in patients older than 50 years: a randomized controlled study

Autor: Bernard Goichot, François Lefebvre, Stéphane Vinzio, Anne Cailleux, Jean-Marc Kuhn, Olivier Schneegans, Bodgan Catargi, Olivier Gilly, Philippe Baltzinger, Nicolas Meyer, Philippe Caron
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: European Thyroid Journal, Vol 13, Iss 6, Pp 1-9 (2024)
Druh dokumentu: article
ISSN: 2235-0802
DOI: 10.1530/ETJ-24-0121
Popis: Objective: Subclinical hyperthyroidism (SCH) is common and associated with atrial fibrillation (AF) risk in the elderly. Current guidelines rely on a low level of evidence. Methods: Randomized clinical trial including patients 50 years and older, with thyroid-stimulating hormone (TSH) 65 years or TSH < 0.1mU/L. Of 94 patients treated using radioiodine, 25% developed hypothyroidism during follow-up. Conclusion: Due to recruitment difficulties, this study failed to demonstrate that SCH treatment can significantly reduce the incidence of AF in patients older than 50 years with thyroid autonomy even if all the patients who developed AF maintained TSH
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