| Autor: |
Nupur Sharma, Sadam H. Bhat, Babu Mathew, Manisha Yadav, Gaurav Tripathi, Vasundhra Bindal, Sanju Yadav, Neha Sharma, Sushmita Pandey, Hami Hemati, Deepika Bohra, Rashmi Rana, Narender K. Sharma, Sanyam Falari, Viniyendra Pamecha, Jaswinder Singh Maras |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Molecular Therapy: Oncology, Vol 32, Iss 4, Pp 200904- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2950-3299 |
| DOI: |
10.1016/j.omton.2024.200904 |
| Popis: |
Carcinoma of the gall bladder (CAGB) has a poor prognosis. Molecular analysis of bile could classify indicators of CAGB. Bile samples (n = 87; training cohort) were screened for proteomics and metabolomics signatures of cancer detection. In bile, CAGB showed distinct proteomic (217 upregulated, 258 downregulated) and metabolomic phenotypes (111 upregulated, 505 downregulated, p 1.5, false discovery rate 0.5, p 90% (p 0.94. Validation of the top four metabolites—toluene, 5,6-DHET, creatine, and phenylacetaldehyde—in separate cohorts (n = 80; bile [T1] and paired plasma [T2]) showed accuracy (99%) and sensitivity/specificity (>98%) for CAGB detection. Tissue validation showed bile 5,6-DHET positively correlated with tissue PCNA (proliferation), and caspase-3 linked to cancer development (r2 >0.5, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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