| Autor: |
Thomas Lanyon-Hogg, Naoko Masumoto, George Bodakh, Antonio D. Konitsiotis, Emmanuelle Thinon, Ursula R. Rodgers, Raymond J. Owens, Anthony I. Magee, Edward W. Tate |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Data in Brief, Vol 7, Iss , Pp 257-281 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
2352-3409 |
| DOI: |
10.1016/j.dib.2016.02.012 |
| Popis: |
In this data article we describe synthetic and characterisation data for four members of the 5-acyl-6,7-dihydrothieno[3,2-c]pyridine (termed “RU-SKI”) class of inhibitors of Hedgehog acyltransferase, including associated NMR spectra for final compounds. RU-SKI compounds were selected for synthesis based on their published high potencies against the enzyme target. RU-SKI 41 (9a), RU-SKI 43 (9b), RU-SKI 101 (9c), and RU-SKI 201 (9d) were profiled for activity in the related article “Click chemistry armed enzyme linked immunosorbent assay to measure palmitoylation by Hedgehog acyltransferase” (Lanyon-Hogg et al., 2015) [1]. 1H NMR spectral data indicate different amide conformational ratios between the RU-SKI inhibitors, as has been observed in other 5-acyl-6,7-dihydrothieno[3,2-c]pyridines. The synthetic and characterisation data supplied in the current article provide validated access to the class of RU-SKI inhibitors. Keywords: Synthesis, Inhibitors, Hedgehog acyltransferase, Conformation |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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