Air pollutants as modulators of mitochondrial quality control in cardiovascular disease

Autor: Kit Neikirk, Chanel Harris, Han Le, Ashton Oliver, Bryanna Shao, Kaihua Liu, Heather K. Beasley, Sydney Jamison, Jeanne A. Ishimwe, Annet Kirabo, Antentor Hinton Jr
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Physiological Reports, Vol 12, Iss 22, Pp n/a-n/a (2024)
Druh dokumentu: article
ISSN: 2051-817X
DOI: 10.14814/phy2.70118
Popis: Abstract It is important to understand the effects of environmental factors such as air pollution on mitochondrial structure and function, especially when these changes increase cardiovascular disease risk. Although lifestyle choices directly determine many mitochondrial diseases, increasingly, it is becoming clear that the structure and function of mitochondria may be affected by pollutants found in the atmosphere (e.g., gases, pesticides herbicide aerosols, or microparticles). To date, the role of such agents on mitochondria and the potential impact on cardiovascular fitness is neglected. Here we offer a review of airborne stressors and pollutants, that may contribute to impairments in mitochondrial function and structure to cause heart disease.
Databáze: Directory of Open Access Journals
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