| Autor: |
Deryl Nii Okantey Kuevi, Jennifer Keiser, Cécile Häberli, Abena Konadu Owusu-Senyah, Mawutor Kwame Ahiabu |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Journal of Tropical Medicine, Vol 2024 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1687-9694 |
| DOI: |
10.1155/2024/8074291 |
| Popis: |
Background. Schistosomiasis is caused by parasitic flatworms and the disease is endemic to most countries in sub-Saharan Africa including Ghana. The current therapeutic agent for managing this disease solely relies on praziquantel. The continual dependence on this single available drug could lead to possible drug resistance. This study seeks to evaluate the antischistosomal activity of the following Ghanaian medicinal plants: Khaya senegalensis, Vernonia amygdalina, Clausena anisata, and Bridelia ferruginea. Methodology. Two concentrations (100 μg/mL and 50 μg/mL) of each extract were tested in a 96-well plate containing 30 newly transformed schistosomula (NTS). Moreover, six worms of both sexes of adult Schistosoma mansoni were exposed to the extracts diluted in the RPMI medium. The assay was performed in a 24-well plate. The parasitic worms were examined using an inverted optical microscope. Results. At 100 μg/mL and 50 μg/mL, all extracts performed better and showed strong activity (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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