Immune Imprinting and Implications for COVID-19

Autor:	Zhiqian Zhou, Julia Barrett, Xuan He
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	B cells immune imprinting humoral immunity vaccines SARS-CoV-2 COVID-19 Medicine
Zdroj:	Vaccines, Vol 11, Iss 4, p 875 (2023)
Druh dokumentu:	article
ISSN:	2076-393X 76020444
DOI:	10.3390/vaccines11040875
Popis:	Immunological memory is the key source of protective immunity against pathogens. At the current stage of the COVID-19 pandemic, heterologous combinations of exposure to viral antigens during infection and/or vaccination shape a distinctive immunological memory. Immune imprinting, the downside of memory, might limit the generation of de novo immune response against variant infection or the response to the next-generation vaccines. Here, we review mechanistic basis of immune imprinting by focusing on B cell immunobiology and discuss the extent to which immune imprinting is harmful, as well as its effect on SARS-CoV-2 infection and vaccination.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/4bd706d76020444891cd302b0d6b0cdf Zobrazit plný text záznamu View record in DOAJ