Expression of membrane-bound β-Klotho on peripheral blood CD4+ and CD8+ T lymphocytes of healthy subjects

Autor: Yana Todorova, Radoslava Emilova, Vesselina Koleva, Ivan Ivanov, Ivan Stoikov, Maria Nikolova
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Biotechnology & Biotechnological Equipment, Vol 37, Iss 1 (2023)
Druh dokumentu: article
ISSN: 13102818
1314-3530
1310-2818
DOI: 10.1080/13102818.2023.2199887
Popis: AbstractImmunosenescence is driven by repeated and continuous immune activation. Sensitive markers are warranted to detect and monitor the process of premature immune ageing. We analysed the β-Klotho expression on T-cell subsets from healthy donors: young adults, n = 12 (20–30 y); middle-aged, n = 62 (30–50 y) and elderly, n = 18 (>70 y). The absolute counts (AC) and percentages of total, CD4+, CD8+ and CD8 + CD27-CD57+ T-cells, CD4/CD8 ratio, and the share of β-Klotho + T-cell subsets were analysed by multicolour flow cytometry. AC of T-cell subsets showed non-significant differences among the groups. The percentages of β-Klotho(+) total, CD4+ and CD8+ T-cells in young adults exceeded significantly the expression in the elderly and middle-aged subjects: (mean) 2.13 vs. 0.48; 3.23 vs. 0.48; 6.87 vs. 2.28, and 0.75 vs. 2.21; 0.93 vs. 3.32; 6.62 vs. 6.62, respectively (p
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