| Autor: |
Jorge Rico-Fontalvo, Maricely Reina, María José Soler, Mario Unigarro-Palacios, Juan Pablo Castañeda-González, Javier Jiménez Quintero, María Raad-Sarabia, Thyago Proença de Moraes, Rodrigo Daza-Arnedo |
| Jazyk: |
English<br />Portuguese |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Brazilian Journal of Nephrology, Vol 46, Iss 4 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2175-8239 |
| DOI: |
10.1590/2175-8239-jbn-2024-0101en |
| Popis: |
Abstract GLP1 receptor agonists (GLP1-RAs) are drugs that mimic the effects of the incretin hormone GLP1 and were initially introduced in medicine for the treatment of diabetes in 2005 and for obesity in 2014. Over time, data from secondary and exploratory objectives of large randomized controlled-trials suggested that GLP1-RAs could also exert renal action by slowing the progression of kidney disease in patients with and without diabetes. Based on this rationale, the Flow study (1 mg semaglutide vs placebo) was designed and recruitment began in 2019 until May 2021. The recently published results confirmed the effect of semaglutide in reducing the composite renal outcome. However, similar to SGLT2 inhibitors, the potential mechanisms behind the renal effects of GLP1-RAs still need to be elucidated. The aim of this review is to address the different physiological mechanisms of GLP1-RAs at the renal level, using evidence from experimental studies and current scientific literature. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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