| Autor: |
Georgios Georgiopoulos, Dimitrios Delialis, Evmorfia Aivalioti, Vasileios Georgakis, Georgios Mavraganis, Lasthenis Angelidakis, Dimitrios Bampatsias, Elena Armeni, Eleni Maneta, Raphael Patras, Maria Angeliki Dimopoulou, Ermioni Oikonomou, Ioannis Kanakakis, Irene Lambrinoudaki, Areti Lagiou, Panos Xenos, Kimon Stamatelopoulos |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Hellenic Journal of Cardiology, Vol 73, Iss , Pp 16-23 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1109-9666 |
| DOI: |
10.1016/j.hjc.2023.02.006 |
| Popis: |
Objective: Sex-specific data are limited regarding eligibility for hypolipidemic treatment. We aim to explore the sex-specific clinical utility of high-sensitivity C-reactive protein (hsCRP) and carotid ultrasound as risk modifiers for hypolipidemic treatment in primary prevention of atherosclerotic cardiovascular disease (ASCVD). Methods: We aimed to explore these sex-specific trends in two pooled contemporary independent Greek cohorts (Athens Vascular Registry n = 698, 50.9% women and Menopause Clinic n = 373, 100% women) of individuals without overt ASCVD. Baseline ASCVD risk was estimated using the Systematic COronary Risk Evaluation-2 (SCORE2) tools. The presence of carotid plaque and hsCRP ≥2 mg/L were integrated as risk modifiers. Results: Men had increased odds to achieve target LDL-C levels based on ASCVD risk (23.8% vs. 17.7%, OR: 1.45 95% CI: 1.05–2.00, p = 0.023, for men vs. women). Additionally, considering carotid plaque or high hsCRP levels did not change this association but reduced on-target LDL-C rate in both sexes. Women had decreased odds of being eligible for hypolipidemic treatment by ASCVD risk estimation (11.5% vs. 26.4%, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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