Structural and biochemical characterization of in vivo assembled Lactococcus lactis CRISPR-Csm complex

Autor: Sagar Sridhara, Jay Rai, Charlisa Whyms, Hemant Goswami, Huan He, Walter Woodside, Michael P. Terns, Hong Li
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-022-03187-1
Popis: This study presents Cryo-EM structures of the Lactococcus lactis Type III-A CRISPR-Cas effector complex in three functional states, including bound forms with cognate and non-cognate target RNA. The results suggest changing protein dynamics during effector complex activation.
Databáze: Directory of Open Access Journals
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