A case of acquired thrombotic thrombocytopenic purpura induced by acute severe hepatitis E: successfully treated by plasma exchange and rituximab

Autor:	Yingwei Ou, Yifan Xu, Zhaowang Tan, Lingxiao Pang, Shengqin Li, Qian Li, Wenwei Cai, Yong Nan, Jianfeng Tu
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Thrombotic thrombocytopenic purpura Hepatitis E virus Plasma exchange Rituximab Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	Thrombosis Journal, Vol 21, Iss 1, Pp 1-4 (2023)
Druh dokumentu:	article
ISSN:	1477-9560
DOI:	10.1186/s12959-023-00507-1
Popis:	Abstract With its low morbidity and high mortality rates, thrombotic thrombocytopenic purpura (TTP) has imposed a critical physical and economic burden on both society and individuals. Thrombocytopenia commonly occurs in severe liver failure, and a variety of hepatitis viruses are known to induce immune thrombocytopenic purpura. However, TTP is extremely rare in hepatitis E virus infection. We hereby report a case of a 53-year-old male who present with TTP caused by severe hepatitis E, and the patients achieved successful recovery after treatment. Therefore, we propose considering AMAMTS13 testing as an essential and beneficial approach for accurately diagnosing and treating patients with severe hepatitis or infection with notable platelet decline.
Databáze:	Directory of Open Access Journals
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