BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors

Autor: Xiaofeng Wang, Su Wang, Emma C. Troisi, Thomas P. Howard, Jeffrey R. Haswell, Bennett K. Wolf, William H. Hawk, Pilar Ramos, Elaine M. Oberlick, Evgeni P. Tzvetkov, Aaron Ross, Francisca Vazquez, William C. Hahn, Peter J. Park, Charles W. M. Roberts
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-09891-7
Popis: Mutations of the SWI/SNF chromatin-remodeling complex member SMARCB1 can cause malignant rhaboid tumors. Here the authors report a BRD9-containing SWI/SNF subcomplex that lacks SMARCB1 and its requirement for the survival of rhaboid tumors.
Databáze: Directory of Open Access Journals