Major infections in newly diagnosed systemic lupus erythematosus: an inception cohort study

Autor: Fangfang Sun, Wanlong Wu, Shuang Ye, Nan Shen, Yi Chen, Shikai Geng, Haiting Wang, Liling Zhao, Danting Zhang, Yuhong Zhou, Liqin Yu
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Lupus Science and Medicine, Vol 9, Iss 1 (2022)
Druh dokumentu: article
ISSN: 2053-8790
DOI: 10.1136/lupus-2022-000725
Popis: Objective To evaluate the risk of major infections and the relationship between major infections and mortality in patients with newly diagnosed SLE.Methods A newly diagnosed (10, peripheral lymphocyte count 104 µmol/L was established to identify patients at low risk (3%–5%) or high risk (37%–39%) of major infections within the first 4 months.Conclusions Newly onset active SLE is susceptible to major infections, which is probably due to underlying profound immune disturbance. Identifying high-risk patients using an appropriate prediction tool might lead to better tailored management and better outcome.
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