A Proof of Principle Study of the Terminal Sterilization of Prefilled Syringes Using A Water Cascade Process

Autor: Drost-Wijnne Anne J.A., Van Wezel Ralph A.C., Deenen Maarten J., Van Doornmalen Gomez Hoyos Joost P.C.M., Grouls René J.E.
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Pharmaceutical Technology in Hospital Pharmacy, Vol 3, Iss 4, Pp 191-198 (2018)
Druh dokumentu: article
ISSN: 2365-2411
2365-242X
2018-0020
DOI: 10.1515/pthp-2018-0020
Popis: A new development in drug compounding is the production of ready-to-administer sterilized prefilled syringes. A challenge with these syringes is the method of terminal sterilization. There is no information available whether water cascade sterilization is a suitable method. We investigated the effect of this sterilization method on cyclic olefin (co)polymer (CCP/COC) syringes.
Databáze: Directory of Open Access Journals