MEDICINAL FORM OF TNF-α FOR LOCAL ADMINISTRATION
| Autor: | S. G. Gamaley, A. V. Bateneva, Z. F. Urmantseva, G. M. Sisoyeva, Ya. V. Markus, E. D. Danilenko, V. K. Mikhaylova, E. A. Volosnikova, G. M. Levagina, V. I. Masicheva |
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| Jazyk: | ruština |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Acta Biomedica Scientifica, Vol 0, Iss 3(2), Pp 264-266 (2012) |
| Druh dokumentu: | article |
| ISSN: | 2541-9420 2587-9596 |
| Popis: | Composite preparation of tumor necrosis factor alpha and rheopolyglukin and polyethylene glycol (TNF-α+PG+PEG) was obtained. The specific activity of the samples was 4,13 х 107 IU/mg. The cytolytic activity of drugs TNF-α+PG+PEG and rhTNF-α did not change after 4 months when stored at 6 °С. Preparation TNF-α+PG+PEG provided a moderately prolonged elevation of TNF-alpha in blood of laboratory mice in contrast to TNF-α when they applied to the skin. The composite preparation did not have toxic, allergic and locally irritating action in experiments on laboratory animals. |
| Databáze: | Directory of Open Access Journals |
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