Complete response with combined BRAF and MEK inhibition in BRAF mutated advanced low-grade serous ovarian carcinoma

Autor:	Bengt Tholander, Anthoula Koliadi, Johan Botling, Hanna Dahlstrand, Anne Von Heideman, Håkan Ahlström, Kjell Öberg, Gustav J. Ullenhag
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	braf inhibitor chemotherapy low-grade serous ovarian cancer mek inhibitor next-generation sequencing surgery targeted therapy v600e mutation Medicine
Zdroj:	Upsala Journal of Medical Sciences, Vol 125, Iss 4, Pp 325-329 (2020)
Druh dokumentu:	article
ISSN:	0300-9734 2000-1967 03009734
DOI:	10.1080/03009734.2020.1826612
Popis:	More effective treatments are needed for low-grade serous ovarian carcinoma (LGSOC). Our patient, who suffers from metastatic LGSOC, had received all established treatments. Sequencing analysis revealed an activating BRAF mutation. Therefore, combined treatment with BRAF and MEK inhibitors, which is the gold standard in malignant melanoma, was initiated. After eight months of therapy, the response was assessed as complete and the treatment is still, 3.5 years after initiation, of benefit. To our knowledge, no complete response on combined BRAF and MEK inhibitor treatment of low-grade serous ovarian cancer has previously been reported.
Databáze:	Directory of Open Access Journals
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