| Autor: |
Neslihan Çoban, Aybike Sena Özuynuk, Aycan Fahri Erkan, Berkay Ekici, Maide Kaşit, Nihan Erginel Ünaltuna |
| Jazyk: |
English<br />Turkish |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Türk Kardiyoloji Derneği Arşivi, Vol 48, Iss 5, Pp 461-471 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1016-5169 |
| DOI: |
10.5543/tkda.2020.62874 |
| Popis: |
Objective: Genetic risk factors that cause coronary artery disease (CAD) demonstrate variations in different populations. In this study, a single nucleotide polymorphism in the APOA5 gene was targeted to determine genetic contributors to atherosclerotic CAD. The effects of this polymorphism on the development of CAD and known risk factors of the disease were examined. Methods: A total of 448 patients with angina or acute myocardial infarction who underwent coronary angiography were grouped as individuals with normal coronary arteries (≤30% stenosis) and critical disease (≥50% stenosis). The angiographic severity and the extent of atherosclerotic CAD were assessed using the Gensini and SYNTAX scores. Individuals were genotyped for the APOA5−1131T>C polymorphism using hydrolysis probes and the results were evaluated. Results: The APOA5−1131T>C polymorphism was associated with the serum lipid levels in the non-CAD group (pC and type 2 diabetes mellitus (p=0.055). This polymorphism was found to be associated with obesity and it was observed that the APOA5 -1131C allele carriers had a reduced risk for obesity (pC polymorphism was associated with important risk factors for CAD, obesity and serum lipid levels. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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