Phase II Trial of Dolastatin-10, a Novel Anti-Tubulin Agent, in Metastatic Soft Tissue Sarcomas
| Autor: | M. von Mehren, S. P. Balcerzak, A. S. Kraft, J. H. Edmonson, S. H. Okuno, M. Davey, S. Mclaughlin, M. T. Beard, A. Rogatko |
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| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: | |
| Zdroj: | Sarcoma, Vol 8, Iss 4, Pp 107-111 (2004) |
| Druh dokumentu: | article |
| ISSN: | 1357-714X 1369-1643 |
| DOI: | 10.1155/2004/924913 |
| Popis: | Patients:Soft tissue sarcomas are uncommon malignancies with few therapeutic options for recurrent or metastatic disease. Dolastatin-10 (Dol-10) is a pentapeptide anti-microtubule agent that binds to tubulin sites distinct from vinca alkaloids. Based on the novel mechanism of action, limited activity of other anti-microtubular agents, and anti-neoplastic activity in pre-clinical screening of Dol-10, this multi-institutional phase II study was conducted to determine the objective response rate of Dol-10 in recurrent or metastatic soft tissue sarcomas that had not been treated with chemotherapy outside of the adjuvant setting. |
| Databáze: | Directory of Open Access Journals |
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