Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability

Autor: A. K. J. Gradel, T. Porsgaard, J. Lykkesfeldt, T. Seested, S. Gram-Nielsen, N. R. Kristensen, H. H. F. Refsgaard
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Journal of Diabetes Research, Vol 2018 (2018)
Druh dokumentu: article
ISSN: 2314-6745
2314-6753
DOI: 10.1155/2018/1205121
Popis: Variability in the effect of subcutaneously administered insulin represents a major challenge in insulin therapy where precise dosing is required in order to achieve targeted glucose levels. Since this variability is largely influenced by the absorption of insulin, a deeper understanding of the factors affecting the absorption of insulin from the subcutaneous tissue is necessary in order to improve glycaemic control and the long-term prognosis in people with diabetes. These factors can be related to either the insulin preparation, the injection site/patient, or the injection technique. This review highlights the factors affecting insulin absorption with special attention on the physiological factors at the injection site. In addition, it also provides a detailed description of the insulin absorption process and the various modifications to this process that have been utilized by the different insulin preparations available.
Databáze: Directory of Open Access Journals
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