| Autor: |
Sankar Renu, Loic Deblais, Veerupaxagouda Patil, Jennifer Schrock, Dipak Kathayat, Vishal Srivastava, Ninoshkaly Feliciano-Ruiz, Yi Han, Anikethana Ramesh, Yashavanth S. Lakshmanappa, Shristi Ghimire, Santosh Dhakal, Gireesh Rajashekara, Gourapura J. Renukaradhya |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Microbiology Spectrum, Vol 10, Iss 3 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2165-0497 |
| DOI: |
10.1128/spectrum.02674-21 |
| Popis: |
ABSTRACT The impact of obesity on the human microbiota, immune maturation, and influenza virus infection has not been yet established in natural host animal models of influenza. In this study, gnotobiotic (Gn) pigs were colonized with human fecal microbiota (HFM) of obese (oHFM) or healthy lean (hHFM) children and infected at different periods (2-, 3-, and 5-weeks post-transplantation) using a zoonotic influenza virus strain. The infected oHFM pigs were characterized by lower levels of Firmicutes (Lactococcus, Lactobacillus, Turicibacter, and Streptococcus) and Actinobacteria (Bifidobacterium), which was associated with higher levels of Proteobacteria (Klebsiella), Bacteroidetes, and Verrucomicrobia (Akkermansia) compared with the infected hHFM group (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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