miR‐922 regulates apoptosis, migration, and invasion by targeting SOCS1 in gastric cancer

Autor: Paerhati Shayimu, Jing‐Bin Wang, Lin Liu, Rousidan Tuerdi, Cun‐Guo Yu, Aikeremu Yusufu
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Kaohsiung Journal of Medical Sciences, Vol 36, Iss 3, Pp 178-185 (2020)
Druh dokumentu: article
ISSN: 2410-8650
1607-551X
DOI: 10.1002/kjm2.12155
Popis: Abstract Gastric cancer (GC) is the second leading cause of cancer‐related death worldwide. Studies have shown that miR‐922 facilitates the development of various diseases and tumors. However, the role of miR‐922 in GC and related molecular mechanisms are still unrevealed. Current study indicated that miR‐922 was overexpressed in GC tissues and cells. The survival rate of patients in high miR‐922 expression group is significantly lower than that in low miR‐922 expression group. In addition, overexpression of miR‐922 observably restrained the apoptosis of SGC7901 cells and promoted SGC7901 cell proliferation, migration, and invasion. TargetScan predicted that suppressors of cytokine signaling 1 (SOCS1) was a potential target of miR‐922. miR‐922 upregulation profoundly inhibited the expression of SOCS1. Furthermore, the mRNA level of SOCS1 in GC tissues was significantly lower than that in adjacent tissues, indicating that miR‐922 promoted the proliferation, invasion, and migration, and inhibited apoptosis of SGC7901 cells by downregulating the level of SOCS1. In conclusion, miR‐922 may have potential for diagnosis of GC.
Databáze: Directory of Open Access Journals
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